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  • Chemistry and Drug development to Quality Assurance Facilitator

    Name: Miss Rosemary Ichaba Course/ job: Quality Assurance (QA) Facilitator & CEO of Financial Support 4 Students (FSS-UK) A levels/ equivalent :Chemistry, Maths ,History Undergrad and post grad degrees: Bsc Chemistry and MSc in Drug Discovery and Pharma Management Journey in 3 Words : Challenging, Rewarding, Growth Briefly describe your role As a QA Facilitator I organise and manage the audits, regulatory and training of the clinical research team within Imperial College.As the CEO of FSS-UK I manage the day-2-day activities of the organisation which includes managing a team, presenting workshops and providing 1-2-1 sessions for students/parents who require the assistance of applying for Non-repayable grants. FSS in the UK : Twitter @fssinuk What motivated you to pursue a career in science? Wanting to make a difference within the pharmaceutical industry and also develop in areas that would have inhibited me from coming out of my comfort zone. How have internships played a role in your career progression? Completing an Internship allowed me to narrow my search of areas that I would like to work in that best fitted my character and personality. It gave me a step into the lingo of the industry and understanding the different areas that make up clinical research, clinical trials and the pharmaceutical industry. What did you enjoy the most about your masters course and looking back what lessons would you give someone wanting to pursue a masters degree? I enjoyed the networking of my class members and with the lecturers. The network I built from my masters allowed me to have a better understanding of how networking can enhance my career choices and decisions. I also enjoyed understanding the science of drug discovery and the business of the pharma industry as it allowed me to pick out roles that I could explore as part of my career development plan. It’s important to manage your time effectively whilst studying a masters and also include time for extra reading to help magnify understanding of each topics. Don’t be afraid to network with all the lecturers that participate within your course, it will be handy when trying to find a role and need advice. Enjoy your masters, knowing that it will be taking you one step forward into the career progression you desire. What advice would you give someone wanting to follow a similar career path? Be open to taking on further responsibilities within a task delegated to you - exploring it further will open you up to more conversations that will give you better knowledge and experience; that can benefit you in the long run. How do you feel careers in your field have evolved / where are they heading to? Due to the effects of Covid-19, we have had to adapt to remote settings of work which has not be easy but have been evolving. Work- Life Balance I try and have working hours that I have set myself to allow for me to have down time from work. I schedule events in advance to ensure that I stick to all my deadlines so there are no interferences with my out of work hours. When considering your career path, how much has your potential salary affected your decision? As I made a shift from Project Management (PM) into Quality Assurance (QA) Auditing, I had to bare in mind that I was starting a role with limited experience and a major room to grow and develop. I had to accept the margin of salary with the intent of growth and promotion within my role and salary. Outside science how would you describe yourself A Gamer - I love playing games, PS games, card games, games Motivator - I love cheering my friends and family to succeed and grow Host - I love cooking and hosting my friends To keep up with Rosemary follow her on socials Instagram: _iamroseefavour Twitter: RoseeVFavour

  • The African Genome Project - Why is it important ?

    Lets take you on a journey as I rekindle my love for genetics, genomics and everything in between. This post explores what the human genome is, why it is important and why the African genome project is massive for science and medical research. KEY WORDS DNA: Letter code of instructions. Gene: Genes are made up of DNA. Genome: If your DNA was read out letter by letter, this is what makes up the genome. Allele: is a different form of a gene . Our DNA is what makes us who we are. It predicts our futures but also remembers our past.My first ever scicomm post was on genetics. I was tasked to write about the importance of DNA. I then found “The out of Africa” theory. In that post, I highlight how our DNA can be used to trace back our origins and show how humans migrated across the globe from Africa. The great human road trip. I wrote that in my first year of university. Since then my understanding of science has grown and so have developments in genomic studies. A huge breakthrough in genomic studies was the completion of the human genome project. The human genome project started in October 1990 and ended in April 2003. The aim of this was to map out the genes. An amazing 15 year project led by scientists across the globe. It set out to completely write out all the letters and codes that make humans, humans. From that, further build and identify points that can help advance medical treatments and more. Human genome project ( HGP) researchers deciphered the human genome in three major ways: determining the order, or "sequence," of all the bases in our genome's DNA; making maps that show the locations of genes for major sections of all our chromosomes; and producing what are called linkage maps, through which inherited traits (such as those for genetic disease) can be tracked over generations. - HGP website What I hadn’t known before, your findings are only as good as your data set.The human genome project, an amazing task was not representative of African populations and for that reason the benefits would be skewed towards the “West” as with a lot of scientific advancements. Since the start of that project, there has been a rise of African researchers, finding and fixing holes in research. This article focuses on two points: Understanding migration within Africa using genomic studies Medical applications and the future of medicine with genomics Understanding migration within Africa Understanding our origins as Africans comes from piecing together migration patterns in early human development. Migration and human origins is a field already heavily studied by historians that can only further be supported by science. With a western lens, we focus on migration patterns leaving Africa, as of course that is relevant human origin for Europeans. For many Africans, migration within the continent is already studied by historians and archaeologists looking past borders created by slavery. The addition of science to history is beautiful to me as there isn’t a world or complete picture where disciplines don't intersect. Bantu migration The Bantu migration is a defining moment in human migration patterns. Historians have already mapped out through linguistics and archaeological studies theories on how this migration has occurred. Genomics and genome data analysis has been able to add to the findings. In my first article about human migration, I explain how our DNA can be used to trace back our origins, specifically our mitochondrial DNA- that is only passed down maternally. In a study bringing together linguistics and genomics to understand Bantu migration, the findings support a “late” theory of migration pattern. In their study they use this method of mitochondrial analysis to try and understand migration patterns. Their findings indicate that migration and dispersal of bantu languages were due to the physical movement of people. This is known as demic diffusion. To support demic diffusion, the genetic data would not have a lot of diversity, ie it would be easier to trace back to a single point. The authors state in their analysis “ lower genetic distances among Bantu populations when compared with those between Bantu and all the other major ethnolinguistic groups, as well as by the reduction of mitochondrial DNA and Y-chromosomal diversity proportional to the distance from the Bantu homeland. Furthermore, we found strong correlations between genetic and linguistic (as well as geographical) distances as additional evidence of a demic diffusion. “ - Bringing together linguistic and genetic evidence to test the Bantu expansion Even with growing scientific evidence to support the diffusion Bantu migration theory of movement of people, there is still debate on the true nature of migration. Perfectly analysed in this review paper: Molecular Perspectives on the Bantu Expansion: A Synthesis . The authors breakdown the complexities in understanding migration patterns using DNA. Mitochondrial DNA is passed down maternally and therefore affected by maternal migration and mixing which will not directly reflect movement of certain populations as earlier generations and cultures adopt paternal languages. In the field, the alternative method for looking back using Y-chromosomal DNA. Y-chromosmal DNA represents paternal lineages. When Y-chromosomal DNA has been used, conflicting evidence of the mass movement of groups have been observed. The review paper highlights the conflicting evidence in the literature and gaps that need to be filled. Such gaps are complex and involve removing biases to confirm physical movement of people, understanding that data is limited and the findings as mentioned are only as good as the sources. Finally the assumption that pre-historical landscape is the same to what we have now can be a hindrance to interpretation of the findings. Moving on from historical analysis, the run-off effects of such analysis and studies go deeper than looking back in time. As DNA can be used to infer timing of movements it can also be used to identify certain traits belonging to groups and regions. The ability of genomic analysis to do this is where its play into medical advancements becomes imperative. A few relatable finding from : High depth African genomes informs human migration and health are: Protection against severe malaria:Eleven single-nucleotide polymorphisms in G6PD associated with protection against severe malaria in heterozygotic female participants Higher frequency of sickle cell mutation where malaria is prevalent: prevalent in East and West africa but nearly absent in South Africa. Using sickle cell disease specific mutations rs334; HbS; MIM 603903) was found at typically high allele frequencies in malaria-endemic west and east African populations. Protection against parasitic infection but increased chance of being susceptible to a different parasite. For example APOL1 G1 and G2 provide protection against Trypanosoma brucei gambiense infection but also increase susceptibility to nephropathy in non-trypanosomiasis endemic areas, especially in the presence of HIV infection and were highest in west African populations. Hypersensitivity to anti retroviral drug Abacavir found in other groups outside the Maasai of Kenya. Previously, the Maasai in Kinyawa, Kenya were the only African population noted to have an appreciable frequency of HLA-B*5701, which mediates hypersensitivity to the antiretroviral drug abacavir. In the expanded dataset, the allele was absent from west African populations, but observed at frequencies typically observed in populations of European or Asian ancestry. Findings like this can help streamline and focus the advancements in science and medicine . The authors of the paper above looked at understudied populations from all the regions within Africa. They looked at gene flow within the groups. Where more differences meant more gene flow . Using points where the genes diverge can give you timestamps as to when populations became their own. Although susceptibility to a disease is not entirely genetic and some cases not at all, as environmental and socieconomic factors have a huge role in health and expression and progression of disease. They were able to confirm and extend risk to disease using sickle cell, HIV, sleeping sickness. Comparing disease susceptibility or adverse reactions based on different populations. Adverse drug reactions are a huge area of research within the pharmaceutical industry as science moves away from generalised medicine and into personalised medicine. There won't always be variations in humans based on genetics but where there are, this can go into making better medicines for certain populations or focusing on most susceptible regions when it comes to certain treatments. To wrap this up, genomics is an ever expanding field with the possibilities endless. It is the work of researchers that want to make a difference that makes this work exciting. Looking back at the article that sparked this blog post: Sequence three million genomes across Africa. In this article researcher Ambroise Wonkam highlightshe gaps in the human genome project (HGP) and how H3Africa aims to extend the work by the (HGP). The importance of a more representative genome wide study comes with complications. With many African countries not having covered the basics when it comes to healthcare, genomics doesn’t seem as important. Governments may be blind to the potential benefits but their is overwhelming evidence of the gains that genomic medicine and scientific research will have on the continent. The use of developing scientific studies brings to the forefront new advancements and technologies and better access to healthcare services that are usually found elsewhere. The paper further highlights that, on bringing these studies, you give people access to better care that they wouldn't otherwise receive. Medical advancements and daily care go hand in hand. there is still much to do to ensure that genomics works for the global public good. The focus on populations from high-income countries has come at the cost of understanding health and disease that might benefit the world. - Ambroise Wonkam References National Geographic - Africa:Human Geography Bringing together linguistic and genetic evidence to test the Bantu expansion Molecular Perspectives on the Bantu Expansion: A Synthesis High depth African genomes informs human migration and health Extra reading Tracing the peopling of the world through genomics

  • Biological science (Medical biology) to Interdisciplinary PhD

    Name : Ramota Adelakun Current Title: PhD Student A levels/ equivalent : Biology, Chemistry, Maths Undergrad and post grad degrees: Bsc Biological sciences (medical biology) with a year abroad Msc – Tropical disease biology Journey in 3 Words: Exhausting, Liberating, Fulfilling What motivated you to pursue a career in science? I have always been fascinated by how people work, it led me to my undergraduate degree and it was here I developed more of an interest into the disease side of things rather than the bodies response. My interest still holds and I want to help translate academic science into something than can be understood by the masses. This is an updated career profile. You can read more about Ramota's Msc journey : Tropical Disease Biology Msc Career Profile and her Year abroad experience Briefly describe your research interests: I am interested in the intersection between biological and social science and science policy development and implementation. My PhD is looking at arsenic and bacterial contamination of drinking water in Bangladesh, and the influence of evidence on developing appropriate health policy. The last time I interviewed you, you were “thinking” about doing a Phd. How did you find your current programme?: I used to narrow down my interests and see what sort of programs existed. Based on that I also identified where I wanted to complete my PhD, and what sort of research I would be happy doing. I did a lot of research on how programmes work and easily determined I wasn't interested in pursuing another masters. I was interested in rotational programmes that would give me a chance to explore further than my previous degrees. My current program offered me all of that. Do you wish you took a break between your Msc and Phd?: Sometimes, and that is mostly because I am exhausted by academia. But i also know that i work best with momentum - so continuing straight on was the best way to ensure that i would actually complete a PhD. What advice would you give your past self?: Stop worrying about what will be, keep doing what you enjoy and the rest will follow Work- Life Balance: I am a big advocate for work life balance, there is no reason why we should come and kill ourselves for work/academia. I ensure that I always get two days a week off. This could be the weekend, or one weekday and one weekend. It just depends on whether i feel like working on particular days and what my work load is like. I also ensure I take University closure days as times off. I dont attend any online meetings and I rarely respond to emails that require me to do immediate work unless I’m letting them know they’ll receive it after the break. I also work hours that suit me best, but ensure I get 6-8hrs sleep. This could be starting at 12pm and finishing at 6pm mostly uninterrupted. What advice would you give on dealing with rejection and perseverance?: Rejection can for the most part teach you what works and what doesn’t. Sometimes rejection is a game of chance, but a lot of the time you simply weren’t the right fit at that right time for that particular thing. Figure out how to re-invest what you want and find the next thing that may fit infinitely better. I also believe that what’s meant for you will never miss you. What do you do outside your direct Phd work and how has that shaped what you plan on doing in the future ? Outside my PhD, I am the founder of the UCL Black Doctoral Student Network. This is a community I fostered in the summer of 2020, to give students the opportunity to relate to one another in a safe environment. As part of this role, I am also curating our first public network event! I have also taught as part of the Brilliant Club, translating my research to Yr9/10 students and showing them what is possible. Furthermore I work as a Teaching assistant, and assist with any other side projects I have the opportunity to dip into. All of these things has helped me to realise my passion for sharing knowledge, and partaking in really good research. I’m excited to see what the future has to bring. Sign up for the UCL Black Doctoral Student Network : Teach me Like I am 5 conference : Friday 4th June 2021 This one-day conference will showcases the talents of Black Doctoral Students across different departments at UCL. All presentations will be developed to be communicated to a non-specific audience. It is inteneded for all audiences. Everyone is encouraged to sign up ! When considering your career path, how much has your potential salary affected your decision?: This is hilarious because about 98%. I work hard and believe in being paid for the value of the work I put. I don’t believe I would work in a Job that doesn’t acknowledge that monetarily. Outside science how would you describe yourself: Introvert, avid tv show binge watcher and all round lover of life and food. To keep up with Ramota you can follow her on twitter : @TheRamota This is an updated career profile. You can read more about Ramota's Msc journey : Tropical Disease Biology Msc Career Profile and her Year abroad experience

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  • Life science careers| thecatalystinme

    bsc Choosing an undergraduate degree is one of the first steps to your life science career. Gain inspiration and discover new courses, is it right for you ? View More Msc So academia is calling you. An Msc/Mres is usually a tremendous task. You don't have to rush into it. View More Grad Every graduate hates the question "what next". Find out how other chose their next steps. View More PHD A Phd takes up the next 3-5 years of your life. Why did others do it? How did they do it? Is it for you? View More Long term The long term plan is important at any stage of your career. Find out what people have done 2+ years after graduation. Here you will also find professionals with more than 10 years experience in their fields View More Featured Posts Adama 6 days ago 3 min Chemistry and Drug development to Quality Assurance Facilitator 4 Write a comment Adama Mar 1 5 min Bsc Medical Physiology to Research Technician 34 Write a comment Adama Feb 22 4 min Bsc Bioscience to Clinical Research Associate 80 Write a comment Adama Feb 8 3 min Phd to CEO l TCIM Careers 11 Write a comment Adama Feb 6 3 min Neuroscience to Freelance science writer l TCIM Careers 29 Write a comment Adama Feb 1 4 min Pharmacology, Biomedical science and Business to Marketing Lead l TCIM Careers 14 Write a comment

  • What do life science graduates do after graduating? l TCIM

    Umu Wurie Biomed to LLM Legal Practice Elicia Fyle Scientific Officer, institute of cancer research. Lynn- Asanate Are Visiting Scientists and Medical Student Allan Campbell Molecular scientist Adama Fullah Pharmacovigilance Business Consultant to Medical Consultant Rachel-Lambert Forsythe Chied Executive British Pharmacological Society Oluwasuen Ogundele Msci Biochemistry to Research assistant at Cambridge Merissa Brown Bsc Biomedical science to Psychology conversion Msc Adama 6 days ago 3 min Chemistry and Drug development to Quality Assurance Facilitator As a QA Facilitator I organise and manage the audits, regulatory and training of the clinical research team within Imperial College 4 views Write a comment Adama Mar 1 5 min Bsc Medical Physiology to Research Technician My Journey from Medical Physiology to Research assistant was't the most straight forward but thus far I have enjoyed it 34 views Write a comment Adama Feb 22 4 min Bsc Bioscience to Clinical Research Associate A CRA monitors clinical trials. Regardless of the role you work in within the pharmaceutical industry the core bioscience skills are used 80 views Write a comment Adama Feb 3 4 min Information, Goals, Decisions l TCIM Career plan In this post, I go through the three points of “The Career Plan” checklist - they somewhat relate so it didn’t make sense to split them up. 1 view Write a comment Adama Feb 1 4 min Pharmacology, Biomedical science and Business to Marketing Lead l TCIM Careers I currently work as marketing lead for UK based biotechnology company Nuchido. 14 views Write a comment Adama Jan 30 4 min Academia is the ghetto- a letter to my naïve self So you have decided academia is the path you want to follow. Motivated, passionate and ready to put in the work. What could go wrong? 22 views Write a comment 2 Adama Dec 4, 2020 4 min Bsc Biology and (MPH) Public Health to Research Manager I TCIM Careers Name: Amran Mohamed Course/ job: Research Project Manager A levels/ equivalent: Biology, Psychology & Economics with AS in Chemistry... 67 views Write a comment 2 Adama Nov 23, 2020 4 min Biomedical Science to Science Writer Name:Amy Brennan (she/her) Job: Science Writer A levels/ equivalent :Biology, Chemistry, Maths (AS Further Maths, Geology) Undergrad and... 22 views Write a comment Adama Nov 15, 2020 4 min Biomedical Science to Phd Cardiovascular scienceI TCIM Careers Name: Jason Amartey Course/ job :PhD Researcher (cardiovascular science) A levels/ equivalent :Biology, Chemistry and Physical Education... 33 views Write a comment 1 Adama Oct 11, 2020 3 min Marine Biology to Chief Executive British Pharmacological Society ITCIM Career Profiles Name: Rachel Lambert-Forsyth (she/her) Job Title: Chief Executive, British Pharmacological Society and Managing Director of BPSA Ltd A... 42 views Write a comment

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